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New theory proposes metabolic dysfunction is a key cause of chronic diseases

A recent article in ScienceDaily presents a study performed at the University of California in San Diego proposing that chronic conditions like diabetes, cancer and cardiovascular disease are “essentially the consequence of the natural healing cycle becoming blocked, specifically by disruptions at the metabolic and cellular levels.”

Dr. Robert Naviaux, author of the study, explains, “The healing process is a dynamic circle that starts with injury and ends with recovery. The molecular features of this process are universal. Emerging evidence shows that most chronic illnesses are caused by the biological reaction to an injury, not the initial injury or the agent of the injury. The illness occurs because the body is unable to complete the healing process.”

“Progressive dysfunction with recurrent injury after incomplete healing occurs in all organ systems, not just the brain,” continues Naviaux. “Chronic disease results when cells are caught in a repeating loop of incomplete recovery and re-injury, unable to fully heal. This biology is at the root of virtually every chronic illness known, including susceptibility to recurrent infections, autoimmune diseases like rheumatoid arthritis, diabetic heart and kidney disease, asthma, chronic obstructive pulmonary disease, Alzheimer’s dementia, cancer and autism spectrum disorder.”

While reading the article and the underlying study I kept thinking of the “wear and tear” caused by eating diets high in carbohydrates that leads to obesity, pre-diabetes and type 2 diabetes.

Over time after many cycles of spikes in blood glucose levels followed by spikes in insulin levels to remove the blood glucose, the body develops insulin resistance and the level of blood glucose remains chronically elevated, which is the definition of type 2 diabetes. Chronically high insulin levels increase fat storage in fat cells, muscles, liver and blood (triglycerides), which causes chronic conditions like inflammation, obesity, non-alcoholic fatty liver disease and cardiovascular disease. The inflammation caused by high glucose levels damage body proteins that cause the complications of diabetes.

A low-carb keto diet decreases these glucose-insulin cycles by eliminating the sugar, starch and processed foods that cause the spikes in blood glucose levels.

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1 Comment

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    Jacqueline Eberstein wrote:

    “… I kept thinking of the “wear and tear” caused by eating diets high in carbohydrates that leads to obesity, pre-diabetes and type 2 diabetes.”

    Exactly. And yet the study authors never want to proceed to the obvious. They always want a drug “solution,” in this case a drug that suppresses ATP. Wait, what? Isn’t ATP required for energy? Do we really need another drug with harmful longterm consequences?

    If you have a headache and you’ve been banging your head with a hammer, how about you just stop? Seems like the same thing here.


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